Michael Ebeid, Ph.D.

Assistant Professor
Downers Grove, IL

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About

Dr. Ebeid is a Neuroscientist interested in mammalian cochlear development and regeneration. Dr. Ebeid received his Master Degree in Anatomy and his Medical Degree from Assiut University in Egypt. He received his Doctor of Philosophy in Biomedical Sciences under the mentorship of Dr. Garrett A. Soukup at Creighton University studying the role of Atoh1 transcription factor and microRNA-183 family members in inner ear hair cell development. He continued on to a postdoctoral fellowship at University of Nebraska Medical Center in Omaha, NE under the mentorship of Dr. Sung-Ho Huh studying the role of fibroblast growth factor signaling and Wnt signaling in cochlear development. Dr. Ebeid joined the faculty at Midwestern University in 2019 where he studies the diversity of cochlear progenitor population, as well as cellular signaling governing progenitor proliferation and differentiation.

Title
Assistant Professor

Campus
Downers Grove, IL

College
College of Graduate Studies - IL

Department
Anatomy

Program
Biomedical Sciences (M.B.S.)
Dental Medicine
Osteopathic Medicine
Physician Assistant Studies

Call My
Office

630-515-6062

Send Me
a Message

mebeid@midwestern.edu

Education

Creighton University | 2016 | Ph.D.
Assiut University | 2009 | M.S.
Assiut University | 2003 | M.B.B.S.

Courses Taught

Lectures on Auditory and Vestibular systems for:

ANATD1521 Neuroscience for Doctor of Osteopathic Medicine (D.O.)

ANATD0565 Neuroscience for Physician Assitant program

IBSSD1521 Neuroscience for Doctor of Dental Medicine (D.M.D.)

ANATD0520 Neuroscience for Master of Biomedical Sciences

Research

Introduction 

About 30 million Americans (12.7 % of the population) suffer from hearing loss. A significant proportion of hearing loss occurs due to damage or defects within the auditory sensory epithelium. Once damaged, the mammalian inner ear lacks the capability to regenerate resulting in irreversible hearing loss. With the exception of cochlear implants, no other effective treatment has been identified. Alternative strategies to regenerate sensory epithelium have been investigated including stem cell and gene therapy, yet the success of such strategies depends on our understanding of the molecular complexity of auditory sensory epithelial development. Some key processes to consider occur early during cochlear epithelium development and include progenitor population proliferation, cell cycle exit and differentiation to either hair cells or supporting cells

Goals

1. Characterize distinct subtypes of progenitor cells and their lineage in the developing mouse cochlea

2. Identify novel genes/pathways involved in progenitor proliferation

3. Generate a novel progenitor cell model to study potential pharmaceutical agents for hair cell regeneration

 

Imgaes of dissected mouse cochlea at different developmental stages

Publications

β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea. Lina Jansson, Michael Ebeid, Jessica W. Shen, Tara E. Mokhtari, Lee A. Quiruz, David M. Ornitz, Sung-Ho Huh, Alan G. Cheng. Proceedings of the National Academy of Sciences Sep 2019, 201910223; DOI: https://doi.org/10.1073/pnas.1910223116

FGF signaling: diverse roles during cochlear development. Michael Ebeid, Sung-Ho Huh. BMB reports 2017. DOI:10.5483/bmbrep.2017.50.10.164

Transcriptome-wide comparison of the impact of Atoh1 and miR-183 family on pluripotent stem cells and multipotent otic progenitor cells. Michael Ebeid, Prashanth Sripal, Jason Pecka, Kirk W. Beisel, Kelvin Kwan, Garrett A. Soukup PLOS ONE July 7, 2017. https://doi.org/10.1371/journal.pone.0180855

 

Organizations

Association for Research in Otolaryngology

https://www.aro.org/

Society For Neuroscience

https://www.sfn.org/

 

 

 

Grants

American Hearing Research Foundation

Mechanism of FGF signaling in regulating mouse cochlear progenitor proliferation

https://www.american-hearing.org/purpose-impact/ahrf-funded-research/grant-recipients/