Lisa Marie Kronstad, Ph.D.

Assistant Professor
Glendale, AZ

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About

Dr. Kronstad received her Ph.D in Microbiology from the University of Berkeley, California in 2013. She completed her postdoctoral fellowship at Stanford University in the Department of Medicine. She joined the faculty at Midwestern University in 2019 as an Assistant Professor. 

Title
Assistant Professor

Campus
Glendale, AZ

College
College of Graduate Studies - AZ
College of Veterinary Medicine

Department
Microbiology & Immunology

Program
Biomedical Sciences (M.B.S.)
Dental Medicine
Optometry
Osteopathic Medicine
Pharmacy
Podiatric Medicine
Veterinary Medicine

Call My
Office

623-572-3725

Send Me
a Message

lkrons@midwestern.edu

Education

University of California
Berkeley | 2013 | Ph.D.
McGill University | 2008 | B.Sc.

Courses Taught

Medical Microbiology MICRG 1615/1616 & 1625/1626

Immunology MICRG 1553

Integrated Basic Sciences 1504-6/1513-15

Veterinary Microbiology II MICRG 1672

Immunology MICRG 1531

 

Research

Vaccines represent the most efficient way to prevent disease with influenza A viruses (IAV) in humans and animals. Unfortunately, the generation of immunity represents a major hurdle of IAV vaccination. Natural killer and Dendritic cells are innate immune cell that traffic rapidly to the lung after infection and are critical for controlling IAV infection in both human and mouse models. However, the precise mechanisms used by IAV to evade or trigger activation of these cells remains unclear. To address these research questions, we use primary human immune cells harvested from blood and a panel of evolutionary distinct IAV strains. Using immunological techniques ‐ such as flow cytometry and ELISA ‐ and viral genetics, we seek to identify the precise viral genes, host pathways and immune signal involved at the interface of IAV infection and innate immunity. Students will be encouraged to develop an independent research project and present their data at scientific conferences.

Publications

Christof Seiler, Lisa M. Kronstad, Laura J. Simpson, Mathieu Le Gars, Elena Vendrame, Catherine A. Blish ,Susan P. Holmes. (2019) Uncertainty Quantification in Multivariate Mixed Models for Mass Cytometry. ArXiv. arXiv:1903.07976.

Lisa M. Kronstad, Christof Seiler, Rosemary Vergara, Susan P. Holmes, Catherine A. Blish. (2018) Differential induction of IFN-α and modulation of CD112 and CD54 expression governs the magnitude of NK cell IFN-γ response to influenza A viruses. J. Immuol. doi:10.4049/jimmunol.1800161

Lisa M. Kronstad, Kevin F. Brulois, Jae U. Jung, and Britt A. Glaunsinger. (2014) Reinitiation after Two Upstream Open Reading Frames Governs Expression of the ORF35-37 KSHV Polycistronic mRNA. J Virol. Jun;88(11):6512-8. doi: 10.1128/JVI.00202-14.

Lisa M. Kronstad, Kevin F. Brulois, Jae U. Jung, and Britt A. Glaunsinger. (2013) Dual Upstream Open Reading Frames Control Translation of a Herpesviral Polycistronic mRNA. PLoS Pathog 9(1): e1003156. doi: 10.1371/journal.ppat.1003156. 

Lisa M. Kronstad and Britt A. Glaunsinger. (2012) Diverse Virus-Host Interactions Influence RNA-based Regulation during Gamma-Herpesvirus Infection. Curr. Opin. Microbiol. 15, 506–511. doi: 10.1016/j.mib.2012.05.010

Cecilia Quiroga, Lisa M. Kronstad, Christine Ritlop, Audrey Filion and Benoit Cousineau. (2011) Contribution of Base Pairing Interactions between Group II Intron Fragments during Trans-splicing in vivo. RNA. 2011 Vol. 17 (12). doi: 10.1261/rna.028886.111

Organizations

American Association of Immunologists 

American Society of Virology 

 

Grants

College of Veterinary Medicine AREA Grant 2019-2020

NIH Institutional Training Grant, 5T32AI007290-29                                                                                                                                                                                                  

Awards

A.P. Giannini Postdoctoral Fellowship

Outstanding Postdoctoral Mentor Award                                                                                                           

NSERC Canada Post-Graduate Scholarship

Natural Sciences and Engineering Research Council (NSERC) Undergraduate Student Research Award